DOD Science Blog Highlights Opioids Research

Michael Feasel, Ph.D., is working to understand the effects of carfentanil at the cellular and systemic levels in order to help determine the dosage of naloxone needed to resuscitate people who have been exposed to the powerful opioid.

The U.S. Department of Defense Science Blog featured an article Feb. 16 that highlights opioids research by Michael Feasel, Ph.D., of the Army's Edgewood Chemical Biological Center, with support from the Defense Threat Reduction Agency's Chemical and Biological Technologies Department, trying to determine how to treat exposure to carfentanil, an especially powerful opioid that "poses a risk to both civilians and warfighters," according to the article.

It explains that carfentanil activates the body's opioid receptors, depressing the respiratory drive and other central nervous system functions. The drug naloxone can reverse the effects of the narcotic, but carfentanil "is so potent that larger doses of naloxone may be required to counter its effects. Currently, little research on the effective dosage is available," it says.

"Higher-potency versions of naloxone are available, however, the Food and Drug Administration has not seen a need to get them approved for human use, until now. These ultra-potent opioid exposures are not only a chemical defense issue, but they are also a public health issue," Feasel says in the article, which says he is working to understand the effects of carfentanil at the cellular and systemic levels in order to help determine the dosage of naloxone needed to resuscitate people who have been exposed to carfentanil. He is collaborating with the National Institute on Drug Abuse in trying to identify metabolites in carfentanil using human liver cells.

Download Center

HTML - No Current Item Deck
  • Free Safety Management Software Demo

    IndustrySafe Safety Management Software helps organizations to improve safety by providing a comprehensive toolset of software modules to help businesses identify trouble spots; reduce claims, lost days, OSHA fines; and more.

  • Get the Ultimate Guide to OSHA Recordkeeping

    When it comes to OSHA recordkeeping there are always questions regarding the requirements and in and outs. IndustrySafe is here to help. We put together this page with critical information to help answer your key questions about OSHA recordkeeping.

  • Safety Training 101

    When it comes to safety training, no matter the industry, there are always questions regarding requirements and certifications. We put together a guide that’s easy to digest so you can ensure you're complying with OSHA's training standards.

  • Conduct EHS Inspections and Audits

    Record and manage your organization’s inspection data with IndustrySafe’s Inspections module. IndustrySafe’s pre-built forms and checklists may be used as is, or can be customized to better suit the needs of your organization.

  • Track Key Safety Performance Indicators

    IndustrySafe’s Dashboard Module allows organizations to easily track safety KPIs and metrics. Gain increased visibility into your business’ operations and safety data.

  • Industry Safe
comments powered by Disqus