FDA Approves New Tablet to Reduce Stroke, Heart Attack Risk

The agency approves Zontivity to reduce the risk of heart attack, stroke and cardiovascular death in high risk patients

The FDA recently approved the drug Zontivity (vorapaxar) to reduce the risk of stroke, heart attack and cardiovascular death in high risk patients, the FDA reports. The tablets also reduce the need for procedures to restore blood flow to the heart. The medication is ideal for use in patients who have previously had a heart attack or blockages in the arteries to the legs.

A clinical trial with over 25,000 patients showed that when added to other anti-platelet agents such as aspirin, Zontivity reduced the rate of a combined endpoint of heart attack, stroke, cardiovascular death and urgent procedures to improve blood flow to the heart.

According to the FDA, Zontivity is “the first in a new class of drug, called a protease-activated receptor-1 (PAR-1) antagonist.” The tablets are designed to decrease the tendency of platelets to clump together and form a blood clot, which in turn decreases the risk of heart attack or stroke. The drug does increase the risk of bleeding, however, and should not be used in people who have had a stroke, transient ischemic attack or bleeding in the head because of the risk of bleeding.  

“In patients who have had a heart attack or who have peripheral arterial disease, this drug will lower the risk of heart attack, stroke, and cardiovascular death. In the study that supported the drug’s approval, Zontivity lowered this risk from 9.5 percent to 7.9 percent over a 3-year period – about 0.5 percent per year,” said Ellis Unger, M.D., director of the Office of Drug Evaluation I in the FDA’s Center for Drug Evaluation and Research, in the FDA’s press release.

Download Center

  • EHS Buyer's Guide

    Download this buyer's guide to make more informed decisions as you're looking for an EHS management software system for your organization.

  • Online Safety Training Buyer's Guide

    Use this handy buyer's guide to learn the basics of selecting online safety training and how to use it at your workplace.

  • COVID Return-to-Work Checklist, Fall 2021

    Use this checklist as an aid to help your organization return to work during the COVID-19 pandemic in a safe and healthy manner.

  • SDS Buyer's Guide

    Learn to make informed decisions while searching for SDS Management Software.

  • Risk Matrix Guide

    Risk matrices come in many different shapes and sizes. Understanding the components of a risk matrix will allow you and your organization to manage risk effectively.

  • Industry Safe

Featured Whitepapers

OH&S Digital Edition

  • OHS Magazine Digital Edition - September 2021

    September 2021

    Featuring:

    • COMBUSTIBLE DUST
      Managing Combustible Dust and Risk Mitigation
    • PPE: CONSTRUCTION
      The Rising Popularity of Safety Helmets on the Jobsite
    • PPE: ELECTRICAL SAFETY
      Five Tips for a Successful Wear Trial
    • SAFETY & HEALTH
      Medical Surveillance Versus Medical Screening
    View This Issue