Study Bolsters Link Between Pesticides, Parkinson's Disease

For the first time, the association between Parkinson's disease and exposure to pesticides has been shown in patients with the neurological disorder compared with their unaffected relatives, according to a study in the online open access journal BMC Neurology.

Parkinson's disease is a common neurological disorder affecting about 1 million people in the United States. The disorder typically develops in later life resulting in symptoms such as tremors and muscle rigidity

Although variations in several genes have been identified that contribute to the disease, these rare genetic defects account for a small proportion of the overall prevalence of the disorder.

The majority of Parkinson's disease cases are thought to be due to an interaction between genetic and environmental factors.

"Previous studies have shown that individuals with Parkinson's disease are over twice as likely to report being exposed to pesticides as unaffected individuals" said the study's lead author, Dana Hancock, "but few studies have looked at this association in people from the same family or have assessed associations between specific classes of pesticides and Parkinson's disease."

The study of related individuals who share environmental and genetic backgrounds that might contribute to Parkinson's disease enables researchers to identify specific differences in exposures between individuals with and without the disease. The research team from Duke University Medical Center (Durham, NC) and the University of Miami Miller School of Medicine Morris K. Udall Parkinson Disease Research Center of Excellence (Miami, FL, USA) recruited 319 patients and over 200 relatives. They used telephone interviews to obtain histories of pesticide exposure, living or working on a farm, and well-water drinking.

The authors detected an association between pesticide use and Parkinson's disease. Among these, the strongest were between the disorder and use of herbicides and insecticides, such as organochlorides and organophosphates. No association was found between Parkinson's disease and well-water drinking or living or working on a farm, which are two commonly used proxies for pesticide exposures.

Many studies have supported pesticides as a risk factor for PD, but "biological evidence is presently insufficient to conclude that pesticide exposure causes PD," said Hancock. "Further investigation of these specific pesticides and others may lead to identification of pertinent biological pathways influencing PD development."

In addition future genetic studies of Parkinson's disease should consider the influence of pesticides, since exposure to pesticides may provide a trigger for the disease in genetically predisposed individuals.

Download Center

HTML - No Current Item Deck
  • Free Safety Management Software Demo

    IndustrySafe Safety Management Software helps organizations to improve safety by providing a comprehensive toolset of software modules to help businesses identify trouble spots; reduce claims, lost days, OSHA fines; and more.

  • Comply with OSHA’s Electronic Recordkeeping Requirements

    Collect relevant incident data and generate accurate OSHA 300, 300A, and 301 regulatory reports, including 300A CSV files for easy electronic submission to OSHA.

  • Complete Online Safety Training Courses

    Deliver state-of-the art, online safety training courses to your organization with IndustrySafe Training Management Software. Generate reports to track training compliance and automatically notify learners of upcoming or overdue classes.

  • Easy to Use Safety Inspection App

    Conduct inspections on the go with IndustrySafe’s mobile app. Complete safety audits at job sites and remote locations—with or without web access.

  • Track Key Safety Performance Indicators

    IndustrySafe’s Dashboard Module allows organizations to easily track safety KPIs and metrics. Gain increased visibility into your business’ operations and safety data.

  • Industry Safe
comments powered by Disqus